Medical Microbiology 7th Edition Test Bank
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Below:
Murray: Medical
Microbiology, 7th Edition
Chapter 10: Immune
Responses to Infectious Agents
Test Bank
MULTIPLE CHOICE
1.
What is the first antibody
produced when an invading microorganism is initially encountered?
|
a.
|
IgA
|
|
b.
|
IgD
|
|
c.
|
IgE
|
|
d.
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IgG
|
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e.
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IgM
|
ANS: E
2.
A 5-day-old baby is
brought back to the hospital with signs of sepsis, is not thriving, and has
vesicular lesions on his scalp at the site of monitor attachment. Why is a baby
susceptible to a more serious outcome with this infection than an older child
or adult?
|
a.
|
Immunosuppression from the mother
|
|
b.
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Infection of a site closest to the brain
|
|
c.
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Lack of IgA production
|
|
d.
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Low levels of interferon-γ production
|
|
e.
|
More rapidly growing cells
|
ANS: D
3.
Endotoxin initiates
septic responses by binding to:
|
a.
|
NF-κB
|
|
b.
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Complement receptor 3d
|
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c.
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Toll-like receptor 4
|
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d.
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C-reactive protein
|
|
e.
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ICAM 1
|
ANS: C
4. Endotoxin induces production of which cytokines by macrophages?
|
a.
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IL-1, TNF-α, IL-6
|
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b.
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IL-2, IL-4, IL-6
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c.
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IL-4, IL-5, IL-10
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d.
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IL-2, IFN-γ, TNF-β
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e.
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TGF-β, IL-10, IL-17
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ANS: A
5.
Which of the following
cytokines is required to initiate a protective helper T cell immune response to
measles virus?
|
a.
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IL-1
|
|
b.
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IL-4
|
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c.
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IL-8
|
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d.
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IL-10
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e.
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IL-12
|
ANS: E
6. Treatment with which cytokine makes the macrophage more
efficient at killing bacteria?
|
a.
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Interferon alpha
|
|
b.
|
Interferon gamma
|
|
c.
|
TGF-β
|
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d.
|
GM-CSF
|
|
e.
|
IL-2
|
ANS: B
7. M. tuberculosis becomes
reactivated in an AIDS patient because:
|
a.
|
CD8 T cells cannot kill the bacteria.
|
|
b.
|
Neutrophils do not become activated.
|
|
c.
|
Macrophages do not get an activation signal.
|
|
d.
|
B cells stop making protective antibody.
|
|
e.
|
CD4 T cells stop making TGF-β.
|
ANS: C
8. Identify which deficiency would most compromise a protective
immune response to E. coli sepsis.
|
a.
|
IgG
|
|
b.
|
IgE
|
|
c.
|
CD8 T cells
|
|
d.
|
Mast cells
|
ANS: A
9. Identify which deficiency would most compromise a protective
immune response to herpes simplex virus.
|
a.
|
IgG
|
|
b.
|
IgE
|
|
c.
|
CD8 T cells
|
|
d.
|
Neutrophils
|
ANS: C
10. Identify which deficiency would most compromise a protective
immune response to poliovirus.
|
a.
|
IgG
|
|
b.
|
IgE
|
|
c.
|
CD8 T cells
|
|
d.
|
Neutrophils
|
ANS: A
11. Identify which deficiency would most compromise a protective
immune response to S. aureus skin infection.
|
a.
|
IgA
|
|
b.
|
IgE
|
|
c.
|
CD8 T cells
|
|
d.
|
Neutrophils
|
ANS: D
12. Identify which deficiency would most compromise a protective
immune response to helminths.
|
a.
|
IgG
|
|
b.
|
IgE
|
|
c.
|
CD8 T cells
|
|
d.
|
Neutrophils
|
ANS: B
13. A person with chronic granulomatous disease and related defects
in the NADPH Oxidase enzyme complex would be most susceptible to serious
outcomes from:
|
a.
|
S. aureus
|
|
b.
|
Herpes simplex virus
|
|
c.
|
Parainfluenza
|
|
d.
|
Neisseria meningitides
|
|
e.
|
All of the above
|
ANS: A
14. A person with complement C7 deficiency would be most susceptible
to serious outcomes from:
|
a.
|
S. aureus
|
|
b.
|
Herpes simplex virus
|
|
c.
|
Parainfluenza
|
|
d.
|
Neisseria meningitides
|
|
e.
|
All of the above
|
ANS: D
15. A person with hyper-IgM syndrome would be susceptible to serious
outcomes from:
|
a.
|
S. aureus
|
|
b.
|
Herpes simplex virus
|
|
c.
|
Parainfluenza
|
|
d.
|
Neisseria meningitides
|
|
e.
|
All of the above
|
ANS: E
16. A person with IgA deficiency would be most susceptible to
serious outcomes from:
|
a.
|
S. aureus
|
|
b.
|
Herpes simplex virus
|
|
c.
|
Parainfluenza
|
|
d.
|
Strongyloides stercoralis
|
|
e.
|
All of the above
|
ANS: C
17. A person with asplenia would be most susceptible to serious
outcomes from:
|
a.
|
S. aureus
|
|
b.
|
Herpes simplex virus
|
|
c.
|
Parainfluenza
|
|
d.
|
Neisseria meningitides
|
|
e.
|
All of the above
|
ANS: D
18. Match the hypersensitivity reaction with the response to poison
ivy.
|
a.
|
Type I
|
|
b.
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Type II
|
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c.
|
Type III
|
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d.
|
Type IV
|
ANS: D
19. Match the hypersensitivity reaction with the anaphylactic
response to penicillin.
|
a.
|
Type I
|
|
b.
|
Type II
|
|
c.
|
Type III
|
|
d.
|
Type IV
|
ANS: A
20. Match the hypersensitivity reaction with the immune
complex–induced complement activation in the kidney during hepatitis B
infection.
|
a.
|
Type I
|
|
b.
|
Type II
|
|
c.
|
Type III
|
|
d.
|
Type IV
|
ANS: C
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